5-Fluorouracil-Induced Hyperammonemic Encephalopathy in a Case of Metastatic Sigmoid Colon Cancer
نویسندگان
چکیده
منابع مشابه
Regorafenib-Induced Hyperammonemic Encephalopathy in Metastatic Colon Cancer
Regorafenib, a multi-targeted tyrosine kinase inhibitor (TKI), is used in metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumors (GIST) for salvageline therapy. From clinical trials, the most commonly reported adverse events of regorafenib are hand-foot skin reactions, fatigue, diarrhea and hypertension. We report two cases of hyperammonemic encephalopathy induced by regorafeni...
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Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy...
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Oxaliplatin-based chemotherapy is widely used to treat advanced cancer. Oxaliplatin-induced hyperammonemic encephalopathy is rarely reported. Here, we report a case of oxaliplatin-induced hyperammonemic encephalopathy occurring after gemcitabine plus oxaliplatin (GEMOX) chemotherapy in a patient with pancreatic cancer. A 76-year-old man received GEMOX regimen as first-line treatment for pancrea...
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A 36-years-old man on phenytoin, levetiracetam, and sodium valproate presented with acute confusion. Routine investigations including serum valproate and phenytoin concentration were normal. His serum ammonia concentration was raised. His valproate was held and 2 days later he recovered with concordant normalisation of serum ammonia concentration. Urea acid cycle disorder was ruled out, and a d...
متن کاملAcute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy.
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following ...
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ژورنال
عنوان ژورنال: Nippon Daicho Komonbyo Gakkai Zasshi
سال: 2018
ISSN: 0047-1801,1882-9619
DOI: 10.3862/jcoloproctology.71.302